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Improved local control without elective nodal radiotherapy in patients with unresectable NSCLC treated by 3D-CRT

YANG Kunyu, LIU Li, ZHANG Tao, WU Gang, CAO Fengjun, WANG Jianhua

《医学前沿（英文）》 2007年 第1卷 第4期   页码 381-385 doi: 10.1007/s11684-007-0074-7

摘要： To investigate the influence of prophylactic elective nodal irradiation on the therapeutic results of definitive radiotherapy for patients with stage IIIA or stage IIIB unresectable non-small-cell lung cancer, 55 patients with clinically inoperable advanced non-small-cell lung cancer were studied. After four cycles of induction chemotherapy, the patients were divided into two groups at random. In one group, the elective nodal irradiation was included in clinical tumor volume (CTV) of definitive radiotherapy (ENI group); and in the other group, elective nodal irradiation was not included in CTV (non-ENI group). For the patients in the ENI group, the mean prescription dose for gross tumor volumes was 58.4 Gy, while for the patients in the non-ENI group, it was 65.8 Gy (<0.05). The responsive rates were 45.8% and 74.0% (<0.05), and the rate of the elective nodal failure (ENF) was 4.2% and 11.1%, respectively. Kaplan-Meier analysis showed that the mean local-progression-free survival time was 11.0 and 15.0 months, and one-year local-failure rates were 51.9% and 24.5% (<0.05). The median overall survival time was 13.0 and 15.0 months, respectively ( = 0.084). The one-year survival rates were 55.7% and 72.5%, and two-year survival rates were 0% and 19.9%. There was no significant difference in the occurrences of radiation-associated complications between the two groups. Our results showed that omitting elective nodal irradiation did not result in a high incidence of elective nodal failure. On the contrary, it decreased local failure by increasing prescription doses to the primary diseases and lymphadenopaphy, and thereby it may further prolong the patients survival.

关键词： significant difference     irradiation     unresectable non-small-cell     induction chemotherapy     influence    

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Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage

《医学前沿（英文）》 2023年 第17卷 第1期   页码 93-104 doi: 10.1007/s11684-021-0892-z

摘要： We conducted a prospective study to assess the non-inferiority of adjuvant chemotherapy alone versus adjuvant concurrent chemoradiotherapy (CCRT) as an alternative strategy for patients with early-stage (FIGO 2009 stage IB–IIA) cervical cancer having risk factors after surgery. The condition was assessed in terms of prognosis, adverse effects, and quality of life. This randomized trial involved nine centers across China. Eligible patients were randomized to receive adjuvant chemotherapy or CCRT after surgery. The primary end-point was progression-free survival (PFS). From December 2012 to December 2014, 337 patients were subjected to randomization. Final analysis included 329 patients, including 165 in the adjuvant chemotherapy group and 164 in the adjuvant CCRT group. The median follow-up was 72.1 months. The three-year PFS rates were both 91.9%, and the five-year OS was 90.6% versus 90.0% in adjuvant chemotherapy and CCRT groups, respectively. No significant differences were observed in the PFS or OS between groups. The adjusted HR for PFS was 0.854 (95% confidence interval 0.415–1.757; P = 0.667) favoring adjuvant chemotherapy, excluding the predefined non-inferiority boundary of 1.9. The chemotherapy group showed a tendency toward good quality of life. In comparison with post-operative adjuvant CCRT, adjuvant chemotherapy treatment showed non-inferior efficacy in patients with early-stage cervical cancer having pathological risk factors. Adjuvant chemotherapy alone is a favorable alternative post-operative treatment.

关键词： chemotherapy     cervical cancer     lymph node metastasis     concurrent chemoradiotherapy     quality of life    

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Constant temperature control of tundish induction heating power supply for metallurgical manufacturing

Yufei YUE, Qianming XU, Peng GUO, An LUO

《能源前沿（英文）》 2019年 第13卷 第1期   页码 16-26 doi: 10.1007/s11708-018-0572-0

摘要： The tundish induction heating power supply (TIHPS) is one of the most important equipment in the continuous casting process for metallurgical manufacturing. Specially, the constant temperature control is greatly significant for metallurgical manufacturing. In terms of the relationship between TIH load temperature and output power of TIHPS, the constant temperature control can be realized by power control. In this paper, a TIHPS structure with three-phase PWM rectifiers and full-bridge cascaded inverter is proposed. Besides, an input harmonic current blocking strategy and a load voltage feedforward control are also proposed to realize constant temperature control. To meet the requirement of the system, controller parameters are designed properly. Experiments are conducted to validate the feasibility and effectiveness of the proposed TIHPS topology and the control methods.

关键词： tundish induction heating power supply (TIHPS)     constant temperature control     input harmonic current blocking     load voltage feedforward    

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allogeneic transplantation could be used as a salvage option for patients with relapsed acute leukemia post-chemotherapy

《医学前沿（英文）》 2021年 第15卷 第5期   页码 728-739 doi: 10.1007/s11684-021-0833-x

摘要： Relapse is the main problem after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The outcome of a second allo-HSCT (HSCT2) for relapse post-HSCT has shown promising results in some previous studies. However, little is known about the efficacy of HSCT2 in patients with relapsed/refractory acute leukemia (AL) post-chemotherapy plus modified donor lymphocyte infusion (post-Chemo+m-DLI) after the first allo-HSCT (HSCT1). Therefore, we retrospectively analyzed the efficacy of HSCT2 in 28 patients with relapsed/refractory AL post-Chemo+m-DLI in our center. With a median follow-up of 918 (457–1732) days, 26 patients (92.9%) achieved complete remission, and 2 patients exhibited persistent disease. The probabilities of overall survival (OS) and disease-free survival (DFS) 1 year after HSCT2 were 25.0% and 21.4%, respectively. The cumulative incidences of nonrelapse mortality on day 100 and at 1 year post-HSCT2 were 7.1%±4.9% and 25.0%±8.4%. The cumulative incidences of relapse were 50.0%±9.8% and 53.5%±9.9% at 1 and 2 years post-HSCT2, respectively. Risk stratification prior to HSCT1 and percentage of blasts before HSCT2 were independent risk factors for OS post-HSCT2, and relapse within 6 months post-HSCT1 was an independent risk factor for DFS and relapse post-HSCT2. Our findings suggest that HSCT2 could be a salvage option for patients with relapsed AL post-Chemo+m-DLI.

关键词： second hematopoietic stem cell transplantation     acute leukemia     relapse     chemotherapy     modified donor lymphocyte infusion    

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Brown and beige fat: the metabolic function, induction, and therapeutic potential

null

《医学前沿（英文）》 2015年 第9卷 第2期   页码 162-172 doi: 10.1007/s11684-015-0382-2

摘要：

Adipose tissue is an important organ for energy homeostasis. White adipose tissue stores energy in the form of triglycerides, whereas brown adipocytes and recently identified beige adipocytes are specialized in dissipating energy by thermogenesis or contribution to dispose glucose and clear triglycerides in blood. The inverse correlation between the brown adipose tissue activity and body mass suggests its protective role against body fat accumulation. Thus, recruitment and activation of brown or beige adipose tissue become particularly appealing targets for increasing energy expenditure. Angiogenesis and sympathetic nerve signals are the fundamental determinants for brown and beige adipose tissue development, as well as for their metabolic functions. Secretary factors including BMPs can induce the development, the activation of brown or beige adipose tissue, which seem to be promising for therapeutic development.

关键词： brown adipocyte     beige adipocyte     metabolism     obesity    

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Estimation of composite load model with aggregate induction motor dynamic load for an isolated hybrid

Nitin Kumar SAXENA,Ashwani Kumar SHARMA

《能源前沿（英文）》 2015年 第9卷 第4期   页码 472-485 doi: 10.1007/s11708-015-0373-7

摘要： It is well recognized that the voltage stability of a power system is affected by the load model and hence, to effectively analyze the reactive power compensation of an isolated hybrid wind-diesel based power system, the loads need to be considered along with the generators in a transient analysis. This paper gives a detailed mathematical modeling to compute the reactive power response with small voltage perturbation for composite load. The composite load is a combination of the static and dynamic load model. To develop this composite load model, the exponential load is used as a static load model and induction motors (IMs) are used as a dynamic load model. To analyze the dynamics of IM load, the fifth, third and first order model of IM are formulated and compared using differential equations solver in Matlab coding. Since the decentralized areas have many small consumers which may consist large numbers of IMs of small rating, it is not realistic to model either a single large rating unit or all small rating IMs together that are placed in the system. In place of using a single large rating IM, a group of motors are considered and then the aggregate model of IM is developed using the law of energy conservation. This aggregate model is used as a dynamic load model. For different simulation studies, especially in the area of voltage stability with reactive power compensation of an isolated hybrid power system, the transfer function of the composite load is required. The transfer function of the composite load is derived in this paper by successive derivation for the exponential model of static load and for the fifth and third order IM dynamic load model using state space model.

关键词： isolated hybrid power system (IHPS)     composite load model     static load     dynamic load     induction motor load model     aggregate load    

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Experimental investigation and comparative study of inter-turn short-circuits and unbalanced voltage supply in induction

Fatima BABAA, Abdelmalek KHEZZAR, Mohamed el kamel OUMAAMAR

《能源前沿（英文）》 2013年 第7卷 第3期   页码 271-278 doi: 10.1007/s11708-013-0258-6

摘要： A transient model for an induction machine with stator winding turn faults on a single phase is derived using reference frame transformation theory. The negative sequence component and the 3rd harmonic are often considered as accurate indicators. However, small unbalance in the supply voltage and/or in the machine structure that exists in any real system engenders the same harmonics components. In this case, it is too difficult to distinguish between the current harmonics due to the supply voltage and those originated by inter-turn short-circuit faults. For that, to have the correct diagnosis and to increase the sensitivity and the reliability of the diagnostic system, it is crucial to provide the relationship between the inter-turn short-circuits in the stator winding and the supply voltage imbalance through an accurate mathematical model and via a series of experimental essays.

关键词： induction machines     fault indicator     inter-turn short-circuit fault     unbalance supply voltage    

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A new and best approach for early detection of rotor and stator faults in induction motors coupled to

Abderrahim ALLAL,Boukhemis CHETATE

《能源前沿（英文）》 2016年 第10卷 第2期   页码 176-191 doi: 10.1007/s11708-015-0386-2

摘要： Today, induction machines are playing, thanks to their robustness, an important role in world industries. Although they are quite reliable, they have become the target of various types of defects. Thus, for a long time, many research laboratories have been focusing their works on the theme of diagnosis in order to find the most efficient technique to predict a fault in an early stage and to avoid an unplanned stopping in the chain of production and costs ensuing. In this paper, an approach called Park’s vector product approach (PVPA) was proposed which was endowed with a dominant sensitivity in the case in which there would be rotor or stator faults. To show its high sensitivity, it was compared with the classical methods such as motor current signature analysis (MCSA) and techniques studied in recent publications such as motor square current signature analysis (MSCSA), Park’s vector square modulus (PVSM) and Park-Hilbert (P-H) (PVSM ). The proposed technique was based on three main steps. First, the three-phase currents of the induction motor led to a Park’s vector. Secondly, the proposed PVPA was calculated to show the distinguishing spectral signatures of each default and specific frequencies. Finally, simulation and experimental results were presented to confirm the theoretical assumptions.

关键词： induction motor     incipient broken bar     extended Park’s vector approach     spectral analysis     inter-turn short-circuit     Hilbert transform    

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Effect of pEGFP-survivin on GBC-SD cell growth and chemotherapy sensitivity

Hanbin SHEN MD, Bin ZHANG MBA, Song ZHAO BM, Qichang ZHENG MD, Jianping GONG MD, Xiaotang CAI BM,

《医学前沿（英文）》 2009年 第3卷 第4期   页码 485-490 doi: 10.1007/s11684-009-0089-3

摘要： This paper is aimed to investigate the effect of survivin shRNA on chemotherapy resistance in human gallbladder carcinoma GBC-SD cells. The viability of human gallbladder carcinoma GBC-SD, GBC-SD/enhanced green fluorescent protein (EGFP), and GBC-SD/survivin cells was detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and mRNA and protein of survivin were tested by reverse transcription-polymerase chain reaction (RT-PCR) and Western blot. After the cells were treated with cisplatin (DDP) (3.0 μg/mL) for the same time, cell survival rate and IC was detected with MTT, cell apoptosis was detected with fluorescence-activated cell sorting (FACS), and the nuclear alteration was observed by TdT-mediated deoxyuridine triphosphate nick end labeling (TUNEL). In addition, caspase-3 activity was detected by using colorimetric method. Cell viability was decreased significantly in GBC-SD/survivin cells, and survivin expression was decreased significantly (mRNA and protein of survivin were decreased by 74.7% and 71.5%, respectively). After treatment with DDP, cell survival rate and IC was decreased significantly (2.03±0.24 μg/mL) in GBC-SD/survivin cells, while apoptotic rate (84.3%) was elevated significantly as compared with the other two groups. There were brown apoptotic nuclei in all the cells. Caspase-3 activity in all the cells was increased at first and then decreased, but the caspase-3 activity in GBC-SD/survivin cells was significantly higher than the other two groups. The survivin shRNA could down-regulate the expression of survivin in GBC-SD cells significantly and improve the sensibility to chemotherapy.

关键词： survivin     shRNA     chemotherapy     sensibility     GBC-SD    

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Multiple target implementation for a doubly fed induction generator based on direct power control under

Heng NIAN,Yi-peng SONG

《信息与电子工程前沿（英文）》 2015年 第16卷 第4期   页码 321-334 doi: 10.1631/FITEE.1400170

摘要： This paper presents a multiple target implementation technique for a doubly fed induction generator (DFIG) under unbalanced and distorted grid voltage based on direct power control (DPC). Based on the mathematical model of DFIG under unbalanced and distorted voltage, the proportional and integral (PI) regulator is adopted to regulate the DFIG average active and reactive powers, while the vector PI (VPI) resonant regulator is used to achieve three alternative control targets: (1) balanced and sinusoidal stator current; (2) smooth instantaneous stator active and reactive powers; (3) smooth electromagnetic torque and instantaneous stator reactive power. The major advantage of the proposed control strategy over the conventional method is that neither negative and harmonic sequence decomposition of grid voltage nor complicated control reference calculation is required. The insensitivity of the proposed control strategy to DFIG parameter deviation is analyzed. Finally, the DFIG experimental system is developed to validate the availability of the proposed DPC strategy under unbalanced and distorted grid voltage.

关键词： Direct power control     Doubly fed induction generator     Unbalanced and distorted grid voltage     Vector proportional and integral resonant regulator     Parameter deviation    

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Application of fuzzy logic control algorithm as stator power controller of a grid-connected doubly-fed induction

Ridha CHEIKH, Arezki MENACER, Said DRID, Mourad TIAR

《能源前沿（英文）》 2013年 第7卷 第1期   页码 49-55 doi: 10.1007/s11708-012-0217-7

摘要： This paper discusses the power outputs control of a grid-connected doubly-fed induction generator (DFIG) for a wind power generation systems. The DFIG structure control has a six diode rectifier and a PWM IGBT converter in order to control the power outputs of the DFIG driven by wind turbine. So, to supply commercially the electrical power to the grid without any problems related to power quality, the active and reactive powers ( , ) at the stator side of the DFIG are strictly controlled at a required level, which, in this paper, is realized with an optimized fuzzy logic controller based on the grid flux oriented control, which gives an optimal operation of the DFIG in sub-synchronous region, and the control of the stator power flow with the possibility of keeping stator power factor at a unity.

关键词： doubly-fed induction generator (DFIG)     vector control     fuzzy logic controller     optimization     power factor unity     active and reactive power    

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A modified neural learning algorithm for online rotor resistance estimation in vector controlled induction

A. CHITRA,S. HIMAVATHI

《能源前沿（英文）》 2015年 第9卷 第1期   页码 22-30 doi: 10.1007/s11708-014-0339-1

摘要： Online estimation of rotor resistance is essential for high performance vector controlled drives. In this paper, a novel modified neural algorithm has been identified for the online estimation of rotor resistance. Neural based estimators are now receiving active consideration as they have a number of advantages over conventional techniques. The training algorithm of the neural network determines its learning speed, stability, weight convergence, accuracy of estimation, speed of tracking and ease of implementation. In this paper, the neural estimator has been studied with conventional and proposed learning algorithms. The sensitivity of the rotor resistance change has been tested for a wide range of variation from -50% to+50% on the stability of the drive system with and without estimator. It is quiet appealing to settle with optimal estimation time and error for the viable realization. The study is conducted extensively for estimation and tracking. The proposed learning algorithm is found to exhibit good estimation and tracking capabilities. Besides, it reduces computational complexity and, hence, more feasible for practical digital implementation.

关键词： neural networks     back propagation (BP)     rotor resistance estimators     vector control     induction motor    

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Clinical outcomes of ATP-tumor chemosensitivity assay directed chemotherapy in hepatocellular carcinoma

RAO Rongsheng, CHEN Wenxue, ZHOU Xinwen, ZHOU Zheng, LI Xiaojun, ZENG Zhiping

《医学前沿（英文）》 2007年 第1卷 第2期   页码 157-160 doi: 10.1007/s11684-007-0029-z

摘要： This study aims to investigate the clinical response of ATP tumor chemosensitivity assay (ATP-TCA) directed chemotherapy regimens delivered via hepatic artery infusion in 104 cases of primary liver carcinoma (PLC). Tumor tissue was obtained via laparotomy and cultivated in vitro. This tissue was put through the assay to determine chemosensitivity. A single drug regimen of either 5-FU, MMC and ADM and a combination drug regimen were used. The treatment assigned was dependent on the result of the ATP-TCA. In the control group, 30 cases of diagnosed PLC were given the conventional three-combination drug. The two groups were evaluated after three courses of chemotherapy. The results are as follows. The overall response rate of sensitivity test ranged from 36% to 44% in the single drug therapy groups and 81% in the combination drug group. The clinical overall response rate was 75% in the treatment group and 56% in control group. The treatment group had better results than the control group as survival period over six months was 80% and over one year 44%. In the control group, survival period over six months was 60% and 30% over one year. In short, ATP-TCA directed chemotherapy shows better results for terminal stages of PLC in that you can decrease the dose of drugs thereby reducing the side-effects with possible improvements in therapeutic effects.
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Toward a nonlinear control of an AC-DC-PWM converter dedicated to induction heating

Amel HADRI-HAMIDA, S. ZEROUALI, A. ALLAG

《能源前沿（英文）》 2013年 第7卷 第2期   页码 140-145 doi: 10.1007/s11708-013-0243-0

摘要： In this paper, a nonlinear control strategy applied to an AC-DC-pulse width modulation (PWM) converter is developed and simulated. First a nonlinear system modeling is derived with state variables of the input current and the output voltage by using power balance of the input and output. The system is linearized and decoupled, and then a state feedback law is obtained. For robust control of parameter perturbation, integrators are added to the exact feedback control law. The simulation is provided to verify the validity of the control algorithm.

关键词： DC-DC converter     AC-DC-pulse width modulation (PWM) converter     induction heating     nonlinear control    

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Effect of ligand chain length on hydrophobic charge induction chromatography revealed by molecular dynamics

Lin ZHANG, Yan SUN

《化学科学与工程前沿（英文）》 2013年 第7卷 第4期   页码 456-463 doi: 10.1007/s11705-013-1357-y

摘要： Hydrophobic charge induction chromatography (HCIC) is a mixed-mode chromatography which is advantageous for high adsorption capacity and facile elution. The effect of the ligand chain length on protein behavior in HCIC was studied. A coarse-grain adsorbent pore model established in an earlier work was modified to construct adsorbents with different chain lengths, including one with shorter ligands (CL2) and one with longer ligands (CL4). The adsorption, desorption, and conformational transition of the proteins with CL2 and CL4 were examined using molecular dynamics simulations. The ligand chain length has a significant effect on both the probability and the irreversibility of the adsorption/desorption. Longer ligands reduced the energy barrier of adsorption, leading to stronger and more irreversible adsorption, as well as a little more unfolding of the protein. The simulation results elucidated the effect of the ligand chain length, which is beneficial for the rational design of adsorbents and parameter optimization for high-performance HCIC.

关键词： adsorption     desorption     irreversibility     protein conformational transition     molecular dynamics simulation    

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标题 作者 时间 类型 操作

Improved local control without elective nodal radiotherapy in patients with unresectable NSCLC treated by 3D-CRT

YANG Kunyu, LIU Li, ZHANG Tao, WU Gang, CAO Fengjun, WANG Jianhua

期刊论文

Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage

期刊论文

Constant temperature control of tundish induction heating power supply for metallurgical manufacturing

Yufei YUE, Qianming XU, Peng GUO, An LUO

期刊论文

allogeneic transplantation could be used as a salvage option for patients with relapsed acute leukemia post-chemotherapy

期刊论文

Brown and beige fat: the metabolic function, induction, and therapeutic potential

null

期刊论文

Estimation of composite load model with aggregate induction motor dynamic load for an isolated hybrid

Nitin Kumar SAXENA,Ashwani Kumar SHARMA

期刊论文

Experimental investigation and comparative study of inter-turn short-circuits and unbalanced voltage supply in induction

Fatima BABAA, Abdelmalek KHEZZAR, Mohamed el kamel OUMAAMAR

期刊论文

A new and best approach for early detection of rotor and stator faults in induction motors coupled to

Abderrahim ALLAL,Boukhemis CHETATE

期刊论文

Effect of pEGFP-survivin on GBC-SD cell growth and chemotherapy sensitivity

Hanbin SHEN MD, Bin ZHANG MBA, Song ZHAO BM, Qichang ZHENG MD, Jianping GONG MD, Xiaotang CAI BM,

期刊论文

Multiple target implementation for a doubly fed induction generator based on direct power control under

Heng NIAN,Yi-peng SONG

期刊论文

Application of fuzzy logic control algorithm as stator power controller of a grid-connected doubly-fed induction

Ridha CHEIKH, Arezki MENACER, Said DRID, Mourad TIAR

期刊论文

A modified neural learning algorithm for online rotor resistance estimation in vector controlled induction

A. CHITRA,S. HIMAVATHI

期刊论文

Clinical outcomes of ATP-tumor chemosensitivity assay directed chemotherapy in hepatocellular carcinoma

RAO Rongsheng, CHEN Wenxue, ZHOU Xinwen, ZHOU Zheng, LI Xiaojun, ZENG Zhiping

期刊论文

Toward a nonlinear control of an AC-DC-PWM converter dedicated to induction heating

Amel HADRI-HAMIDA, S. ZEROUALI, A. ALLAG

期刊论文

Effect of ligand chain length on hydrophobic charge induction chromatography revealed by molecular dynamics

Lin ZHANG, Yan SUN

期刊论文